GREPI Team

TEAM 1 : RESEARCH AND STUDY GROUP FOR INFLAMMATORY PROCESS (GREPI)

L’activité de recherche du GREPI est résolument tournée dans des modèles humains pour développer des connaissances pouvant être directement valorisées au bénéfice des soins et de l’activité économique.

Research themes

Activité des NADPH oxydases, Nox: relations structure-fonction, régulation et dysfonctionnement
Activation des protéases : système producteur et catabolisme des kinines
Conséquences pathologiques
Valorisation
Biomarqueurs dans les maladies chroniques (Plateforme BioPark d'Archamps)

Publications

Jacquemont S,…, Coutton C,…, Satre V,…, Froguel P. Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature. 2011 ; 478(7367):97-102 (SJR 0% Multidisciplinary Q1)

Roncoroni C, Baillet A, Durand M, Juvin R, Gaudin P. Efficacy and tolerance of systemic steroids in acute sciatica: a systematic review and meta-analysis. Rheumatology. 2011; vol 50: pp. 1603-11 (SJR top 6% Rheumatology Q1)

Takac I, Schröder K, Zhang L, Lardy B, Anilkumar N, Lambeth JM, Shah AM, Morel F, Brandes RP. The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4. J Biol Chem. 2011; vol 286: pp. 13304-13 (SJR top 5% Biochemistry Q1)

Baillet A, Vaillant M, Guinot M, Juvin R, Gaudin P. Efficacy of resistance exercises in rheumatoid arthritis: Metaanalysis of randomized controlled trials. Rheumatology. 2012; vol 51: pp. 519-27 (SJR top 6% Rheumatology Q1)

Berthier S, Nguyen MVC, Baillet A, Hograindleur MA, Paclet MH, Polack B, Morel F. Molecular interface of S100A8 with cytochrome b558 and NADPH oxidase activation. PloS ONE. 2012; in press (SJR top 3% Agricultural and Biological Sciences (miscellaneous) Q1)

Dentan C, Mazet R, Gilson M, Marchou-Lopez S, Gaudin P. Rheumatoid arthritis, alveolar echinococcosis and rituximab: a case report. Joint Bone Spine. 2012; vol 79: pp. 325-7 (SJR top 11% Orthopedics and Sports Medicine)

Ejlerskov P, Ploug D, Beyaie D, Burritt JB, Paclet MH, Gorlach A, van Deurs B, Vilhardt F. NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B-regulated secretory compartment in activated macrophages. J Biol Chem. 2012 vol 287: pp 4835-52. (SJR top 7% Biochemistry Q1)

Mertes PM, Demoly P, Alperovitch A, Bazin A, Bienvenu J, Caldani C, Lamy B, Laroche D, Leconte des Floris MF, Py Y, Rebibo D, Willaert B, Drouet C, Carlier M, Lienhart A. Methylene blue-treated plasma. An increased allergy risk? J Allergy Clin Immunol. 2012; in press (SJR top 7% Immunology Q1)

Nguyen MVC, Du F, Felice C, Shan X, Nigam A, Mandel G, Robinson J, Ballas N. MeCP2 is critical for maintaining mature neuronal networks and global brain anatomy during late stages of postnatal brain development and in the mature adult brain. J Neurosci. 2012; in press (SJR top 5% Neuroscience Q1)

Le Friec G, Sheppard D, Whiteman P, Karsten CM, Al-Tilib Shamoun S, Laing A, Bugeon L, Dallman MJ, Melchionna T, Chillakuri C, Smith RA, Drouet C, Couzi L, Fremeaux-Bacchi V, Köhl J, Waddington SN, McDonnell JM, Baker A, Handford PA, Lea SM, Kemper C. The novel Jagged1 and CD46 interaction on T lymphocytes mediates a critical defence mechanism of human adaptive TH1 immunity. Nature Immunology 2012; in press (IF= 26, rank 3/151 in Immunology Q1)